The Global In vivo (CRO) Market is anticipated to achieve a Compound Annual Growth Rate (CAGR) of 8.2%, increasing from USD 3.61 Billion in 2020 to USD 6.44 Billion by 2028. The market growth is driven by several factors, including the pharmaceutical industry's preference for outsourcing clinical and preclinical trials to concentrate on core business activities, the growing trend of outsourcing research and development (RD) activities, the rising number of patients and the prevalence of various diseases worldwide, which leads to an increased demand for CRO services. An example of a notable achievement in the industry is the USDA inspection passed by BTS Research without any errors in clinical trials in December 2018.

In vivo experiments involve conducting research within living organisms, as opposed to in situ experiments that focus on specific genes or proteins. In contrast, in vitro experiments are conducted outside of living organisms. During the COVID-19 pandemic, in vivo contract research organizations have been actively involved in various life science activities in response to the outbreak.

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Companies considered in this market study:

American Preclinical Services, LLC, BTS Research, Charles River Laboratories, Chiltern International Ltd., Crown Bioscience, Eurofins Scientific, Evotec, ICON PLC, INC Research, inVentiv Health, Parexel International, Pharmaceutical Product Development, LLC (PPD), PRA Health Sciences, Quintiles, Taconic Biosciences and Theorem Clinical Research, others are leading players involved on the global In vivo CRO market.

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Factors driving the In vivo CRO market:

1. Increasing outsourcing of clinical and preclinical trials: Pharmaceutical companies are increasingly outsourcing their clinical and preclinical trials to CROs. This allows them to focus on their core competencies while leveraging the specialized expertise and infrastructure of CROs, thereby driving the growth of the In vivo CRO market.
2. Growing RD activities: The frequency of outsourcing research and development (RD) activities to CROs is increasing. CROs offer comprehensive services for study design, data collection, analysis, and reporting, which helps accelerate the drug development process and reduce costs, thus driving market growth.
3. Rising prevalence of diseases: The global increase in the occurrence of various diseases, including chronic conditions, cancer, and infectious diseases, is driving the demand for clinical trials and research services provided by In vivo CROs. This demand stems from the need to develop and test new treatments, vaccines, and therapies.
4. Advancements in technology and expertise: In vivo CROs continually adopt advanced technologies, such as molecular imaging, genomics, and biomarker analysis, to enhance their research capabilities. These technological advancements, coupled with the specialized expertise of CROs, attract pharmaceutical companies to outsource their studies, stimulating market growth.

Factors restraining the In vivo CRO market:

1. Regulatory and compliance challenges: The clinical trial process is highly regulated, and CROs must comply with stringent regulatory requirements. Challenges in meeting these regulatory standards, obtaining necessary approvals, and ensuring patient safety can present barriers to the growth of the In vivo CRO market.
2. Intellectual property concerns: Outsourcing research activities to CROs may raise concerns about protecting intellectual property and maintaining confidentiality. Pharmaceutical companies may hesitate to outsource certain studies or disclose proprietary information, potentially limiting market growth.
3. Pricing pressure and cost constraints: The pricing and cost structure of In vivo CRO services can be a restraining factor. Pharmaceutical companies may face budget constraints or seek cost-effective alternatives, such as conducting studies in-house or utilizing other research models, impacting the demand for In vivo CRO services.
4. Competition from alternative research models: In vivo studies are one of several research models available, including in vitro studies, computer simulations, and human-based clinical trials. The availability and suitability of alternative research models may pose competition and limit the growth potential of the In vivo CRO market.

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