RNA Therapeutics Market Size, Share, Growth Factors, Competitive Landscape, with Regional Forecast to 2035

Owing to their clinical potential to specifically target and treat various disease indications, the next generation RNA therapeutics and vaccines have gained significant traction and are anticipated to revolutionize the healthcare and medical sector.

The global RNA therapeutics and vaccines market size is estimated to grow from USD 1.2 million in 2023 to USD 948 million by 2035, representing a CAGR of 68% during the forecast period 2023-2035.
Over the years, RNA-based therapeutics and vaccines have been studied extensively for their crucial role in gene function and protein expression regulation. Owing to their vast potential in the treatment of a myriad of disease indications, targeting previously deemed undruggable targets, and high therapeutic efficiency, these molecules have transitioned into a compelling treatment alternative for a range of disorders. However, a major challenge in the implementation of these therapies lies in the highly unstable structure of the RNA molecule. The loose prime terminals of RNA molecules allow quick degradation of these molecules by restriction exonucleases. In recent years, the advent of advanced technologies and platforms has escalated the interest of industry stakeholders towards enhanced and modified RNA-based therapies, that are believed to be highly stable and have an extended impact at relatively low doses.
The types of next generation RNA therapeutics and RNA vaccines include circular RNA (circRNA), endless RNA (eRNA), self activating RNA (sacRNA), self amplifying RNA (saRNA), self amplifying mRNA (samRNA), replicating RNA (repRNA) and transfer RNA (tRNA). The success of these next generation RNA therapeutics and RNA vaccines can be attributed to their structural stability, expression specificity, targeted delivery, non-immunogenic nature, high efficiency and ability to target a wide range of therapeutic modalities, including influenza, COVID-19 infection, breast cancer and interstitial lung disease, among others.
Next generation RNA therapeutics and RNA vaccines offer great promise in the healthcare sector, as a result of which, various drug and technology developers are shifting their focus towards the design, development, manufacturing and delivery of these innovative modalities.
Given the ongoing pace of innovation in this field, encouraging clinical trial results, accelerated approvals, and the continuous efforts of both industry and non-industry players, the next generation RNA vaccines and RNA therapeutics market is likely to witness significant growth during the forecast period.
Over 35 next generation RNA technologies are being developed / offered by companies for the research, discovery, design, development, manufacturing and delivery of novel rna therapies and vaccines.
Currently, over 35 next generation RNA technologies are being developed / offered by industry players. It is worth mentioning that most of the technologies are being deployed for next generation RNA based therapeutics. Examples of technologies used in the development of both self-amplifying RNA therapeutics and vaccines include ChaESAR Technology and VaxEquity’s Next-generation RNA Platform.
The number and geographical distribution of clinical trials are important indicators of both the therapeutic viability and future potential of innovative pharmacological interventions. Over the years, several pharmaceutical / biopharmaceutical companies have conducted extensive clinical studies for only those drug / therapy classes that are likely to translate into commercial success. Moreover, the geographical distribution directly indicates the various markets that are open to receiving / adopting the intervention under investigation. As more product candidates get approved by the regulatory authorities across the globe, the number of clinical trials across different global regions is anticipated to increase.
There was a steady increase in the number of clinical trials registered for the evaluation of next generation RNA therapeutics and vaccines, during the period 2019-2023. This increase can be attributed to the incessant efforts of several industry / non-industry players that are actively developing and testing different types of novel RNA-based approaches for the treatment of a wide range of disorders. It is also worth highlighting that, over the years, most of the trials (33%) were registered in 2022.
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